BASIC RESIDUES R260 AND K357 AFFECT THE CONFORMATIONAL DYNAMICS OF THE MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER LMRP.

Basic residues R260 and K357 affect the conformational dynamics of the major facilitator superfamily multidrug transporter LmrP.

Secondary-active multidrug transporters can confer resistance on cells to pharmaceuticals by mediating their extrusion away from intracellular targets via substrate/H(+)(Na(+)) antiport.While the interactions of catalytic carboxylates in these transporters with coupling ions and substrates (drugs) have been studied in some detail, Computer HDD Moun

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Merits and Limitations of Studying Neuronal Depolarization-Dependent Processes Using Elevated External Potassium

Elevated extracellular potassium chloride is widely used to achieve membrane depolarization of cultured neurons.This technique has illuminated mechanisms of calcium influx through L-type voltage Clothing - Mens Bottoms - Shorts sensitive calcium channels, activity-regulated signaling, downstream transcriptional events, and many other intracellular

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Kerusakan Hati Akibat Keracunan Alkohol Berulang pada Tikus Wistar (LIVER DAMAGE DUE TO ALCOHOL INTOXICATION REPEAT IN WISTAR RATS)

The aims of this study was to determine the liver damage from alcohol intoxication in Wistar rats.The design used in this study was a randomized true experimental post test only control group design.Thestudy used 15 rats divided into 3 treatment groups each of which consists of 5 rats.The first group wasgiven distill water.The second group was give

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Assessment of Patients Monitored for Non-Biliary Acute Pancreatitis in Terms of Etiology, Prognosis, and Mortality

INTRODUCTION: We planned to investigate the etiologic causes, prognosis, and mortality rates for cases diagnosed with non-biliary acute pancreatitis (AP) monitored by the internal medicine clinic.METHODS: The study included 73 patients monitored by the clinic from January 2016 to June 2021.Patients included in the assessment were investigated for a

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