Basic residues R260 and K357 affect the conformational dynamics of the major facilitator superfamily multidrug transporter LmrP.
Secondary-active multidrug transporters can confer resistance on cells to pharmaceuticals by mediating their extrusion away from intracellular targets via substrate/H(+)(Na(+)) antiport.While the interactions of catalytic carboxylates in these transporters with coupling ions and substrates (drugs) have been studied in some detail, Computer HDD Moun